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- Precautions Long-term treatment with Premarin may increase risk of breast cancer, endometrial hyperplasia, heart attack, or stroke so monitoring of the patient’s state should be done on a regular basis.
- Erythromycin, ketoconazole Nizoral, itraconazole Sporanox, and ritonavir Norvir act oppositely.
- Cautiousness should be exercised in patients with thrombophlebitis, thrombosis or thromboembolism while taking estrogens in history ; family hyperlipoproteinemia, pancreatitis, endometriosis, gallbladder disease in history especially cholelithiasis, severe liver failure, jaundice including one during pregnancy in history, hepatic porphyria, leiomyoma, hypercalcemia associated with bone metastases caused by breast cancer, underactive thyroid, porphyria, endometriosis, asthma.
- Storage Premarin should be stored at room temperature, between 15-30 C 59-86 F.
- Contraindication Hypersensitivity, pregnancy, breastfeeding, estrogen depending malignant tumors, undiagnosed genital or uterine bleeding, thrombophlebitis or thromboembolic disease in active phase excluding treatment of breast and prostate cancers.